Anti-MKP-1/DUSP1 Antibody Picoband® Fluoro647 Conjugated

Dual specificity protein phosphatase 1 is an enzyme that in humans is encoded by the DUSP1 gene. The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy.

Arachidonate 12-lipoxygenase, 12S-type;12S-LOX;12S-lipoxygenase;1.13.11.31; Lipoxin synthase 12-LO;3.3.2.-; Platelet-type lipoxygenase 12; ALOX12;12LO, LOG12

A synthetic peptide corresponding to a sequence at the N-terminus of human MKP-1/DUSP1, which shares 96.3% amino acid (aa) sequence identity with both mouse and rat MKP-1/DUSP1.

Cardiovascular, Cell Biology, Cell Cycle, Cell Differentiation, Lipases, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction

Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S) - hydroperoxyeicosatetraenoic acid/ (12S) -HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S) -HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation. .

1. Alessi, D. R., Smythe, C., Keyse, S. M. The human CL100 gene encodes a tyr/thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts. Oncogene 8: 2015-2020, 1993. 2. Bhalla, U. S., Ram, P. T., Iyengar, R. MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Science 297: 1018-1023, 2002. 3. Brondello, J.-M., Pouyssegur, J., McKenzie, F. R. Reduced MAP kinase phosphatase-1 degradation after p42/p44 (MAPK) -dependent phosphorylation. Science 286: 2514-2517, 1999.