Anti-C3 Antibody Picoband® Fluoro488 Conjugated

Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients.

E.coli-derived human C3 recombinant protein (Position: Q1277-E1538) . Human C3 shares 73.7 % and 76.3% amino acid (aa) sequence identity with mouse and rat C3, respectively.

Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NFKB and MAPK pathways. Acts synergically with IL22, TNF and IL1B in inducing antibacterial peptides. May have protective function by maintaining epithelial homeostasis after an inflammatory challenge, such as that caused in the intestine by dextran sulfate sodium in a colitis model. May also promote an inflammatory phenotype, such as skin in a psoriasis model. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases, such as autoimmune encephalitis.

1. Ajees, A. A., Gunasekaran, K., Volanakis, J. E., Narayana, S. V. L., Kotwal, G. J., Krishna Murthy, H. M. The structure of complement C3b provides insights into complement activation and regulation. Nature 444: 221-225, 2006. Note: Retraction: Nature 532: 268 only, 2016. 2. Alper, C. A., Colten, H. R., Gear, J. S. S., Rabson, A. R., Rosen, F. S. Homozygous human C3 deficiency: the role of C3 in antibody production, C1s-induced vasopermeability, and cobra venom-induced passive hemolysis. J. Clin. Invest. 57: 222-229, 1976. 3. Alper, C. A., Colten, H. R., Rosen, S. F., Rabson, A. R., MacNab, G. M., Gear, J. S. S. Homozygous deficiency of C3 in a patient with repeated infections. Lancet 300: 1179-1181, 1972. Note: Originally Volume II.