Anti-TMBIM1 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Transmembrane BAX inhibitor motif-containing protein 1 is a protein that in humans is encoded by the TMBIM1 gene. TMBIM1 is a member of the 7 TMS (7 transmembrane domains) family of receptors known to mediate the activation of various transcription factors. TMBIM1 is identified as a novel modulator of NF-kB activation. A drosophila homolog of this protein (dNMDA1 with 40% homology to hTMBIM1) is reported to be unregulated during aging and oxidative stress.
Synonyms
E3 ubiquitin-protein ligase RNF169; RING finger protein 169; RING-type E3 ubiquitin transferase RNF169; RNF169; KIAA1991
Gene Name
TMBIM1
Gene ID
64114
UniProt
Q969X1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human TMBIM1, which shares 87.5% and 93.8% amino acid (aa) sequence identity with mouse and rat TMBIM1, respectively.
Clonality
Polyclonal
Tissue Specificity
Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow.
Applications
Flow Cytometry
Field of Research
Hematopoietic Progenitors, Lymphoid, Stem Cells, T Lymphocytic Lineage
Purification
Immunogen affinity purified.
Form
Liquid
Function
Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair.
References & Citations
1. Yoshisue, H., Suzuki, K., Kawabata, A., Ohya, T., Zhao, H., Sakurada, K., Taba, Y., Sasguri, T., Sakai, N., Yamashita, S., Matsuzawa, Y., Nojima, H. Large scale isolation of non-uniform shear stress-responsive genes from cultured endothelial cells through the preparation of a subtracted cDNA library. Atherosclerosis 162: 323-334, 2002. 2. Zhao, H., Ito, A., Kimura, S. H., Yabuta, N., Sakai, N., Ikawa, M., Okabe, M., Matsuzawa, Y., Yamashita, S., Nojima, H. RECS1 deficiency in mice induces susceptibility to cystic medial degeneration. Genes Genet. Syst. 81: 41-50, 2006. 3. Zhao, H., Ito, A., Sakai, N., Matsuzawa, Y., Yamashita, S., Nojima, H. RECS1 is a negative regulator of matrix metalloproteinase-9 production and aged RECS1 knockout mice are prone to aortic dilation. Circ. J. 70: 615-624, 2006.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
41409 MW
Applications Notes
6
Gene Name Synonym
Ring finger protein 169
Subcellular Location
Nucleoplasm.
Protein Name
Protein NDRG3
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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