Anti-Galectin 2/LGALS2 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Galectin-2 is a protein that in humans is encoded by the LGALS2 gene. The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction.
Synonyms
Olfactomedin-4; OLM4; Antiapoptotic protein GW112; G-CSF-stimulated clone 1 protein; hGC-1; hOLfD; OLFM4; GW112; UNQ362; PRO698
Gene Name
LGALS2
Gene ID
3957
UniProt
P05162
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human Galectin 2/LGALS2 recombinant protein (Position: M1-E132) .
Clonality
Polyclonal
Tissue Specificity
Expressed during myeloid lineage development. Much higher expression in bone marrow neutrophils than in peripheral blood neutrophils (at protein level) . Strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone marrow and stomach. Overexpressed in some pancreatic cancer tissues.
Applications
Flow Cytometry
Field of Research
Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin.
References & Citations
1. Gitt, M. A., Barondes, S. H. Evidence that a human soluble beta-galactoside -binding lectin is encoded by a family of genes. Proc. Nat. Acad. Sci. 83: 7603-7607, 1986. 2. Gitt, M. A., Barondes, S. H. Genomic sequence and organization of two members of a human lectin gene family. Biochemistry 30: 82-89, 1991. 3. Gitt, M. A., Massa, S. M., Leffler, H., Barondes, S. H. Isolation and expression of a gene encoding L-14-II, a new human soluble lactose-binding lectin. J. Biol. Chem. 267: 10601-10606, 1992.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
211344 MW
Applications Notes
6
Gene Name Synonym
Olfactomedin 4
Subcellular Location
Extracellular space. Mitochondrion.
Protein Name
Chromodomain-helicase-DNA-binding protein 2
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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