Anti-Carbonic Anhydrase 13/CA13 Antibody Picoband® Fluoro550 Conjugated
Product Specifications
Background
Carbonic anhydrase 13 is a protein that in humans is encoded by the CA13 gene. Carbonic anhydrases (CAs) are a family of zinc metalloenzymes that catalyze the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid (i.e. bicarbonate and hydrogen ions) .
Synonyms
Homer protein homolog 3; Homer-3; HOMER3
Gene Name
CA13
Gene ID
377677
UniProt
Q8N1Q1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human Carbonic Anhydrase 13/CA13, which shares 85% and 55% amino acid (aa) sequence identity with mouse and rat Carbonic Anhydrase 13/CA13, respectively.
Clonality
Polyclonal
Tissue Specificity
Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Applications
Flow Cytometry
Field of Research
Receptors / Channels, Synapse Marker
Purification
Immunogen affinity purified.
Form
Liquid
Function
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.
References & Citations
1. Lehtonen, J., Shen, B., Vihinen, M., Casini, A., Scozzafava, A., Supuran, C. T., Parkkila, A.-K., Saarnio, J., Kivela, A. J., Waheed, A., Sly, W. S., Parkkila, S. Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family. J. Biol. Chem. 279: 2719-2727, 2004.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
39836 MW
Applications Notes
6
Gene Name Synonym
Homer protein homolog 3
Subcellular Location
Cytoplasm . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Cell junction, synapse . Postsynaptic density of neuronal cells. .
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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