Anti-TSG101 Antibody Picoband® Fluoro488 Conjugated

TSG101, known as Tumor susceptibility gene 101, is mapped to 11p15. The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. And the protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression.

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

1. Entrez Gene: TSG101 tumor susceptibility gene 101. 2. Lu Q, Hope LW, Brasch M, Reinhard C, Cohen SN (June 2003) . TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation.Proc. Natl. Acad. Sci. U.S.A. 100 (13) : 7626–31. 3. Sun Z, Pan J, Hope WX, Cohen SN, Balk SP (August 1999) . Tumor susceptibility gene 101 protein represses androgen receptor transactivation and interacts with p300. Cancer 86 (4) : 689–96.