Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-TRPC3 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Short transient receptor potential channel 3 (TrpC3) also known as transient receptor protein 3 (TRP-3) is a protein that in humans is encoded by the TRPC3 gene. The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene.

Synonyms

Short transient receptor potential channel 3; TrpC3; Transient receptor protein 3; TRP-3; hTrp-3; hTrp3; TRPC3; TRP3

Gene Name

TRPC3

Gene ID

7222

UniProt

Q13507

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human TRPC3, which shares 94.4% amino acid (aa) sequence identity with both mouse and rat TRPC3.

Clonality

Polyclonal

Tissue Specificity

Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis.

Applications

Flow Cytometry

Field of Research

Calcium Channels, Calcium Signaling, Cardiovascular, Hypertrophy, Neurogenesis, Neurology Process, Neuroscience, Signal Transduction, Signaling Pathway, Vasculature

Purification

Immunogen affinity purified.

Form

Liquid

Function

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5- triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion. .

References & Citations

1. Fusco FR, Martorana A, Giampà C, De March Z, Vacca F, Tozzi A, Longone P, Piccirilli S, Paolucci S, Sancesario G, Mercuri NB, Bernardi G (July 2004) . Cellular localization of TRPC3 channel in rat brain: preferential distribution to oligodendrocytes. Neuroscience Letters. 365 (2) : 137–42. 2. Li HS, Xu XZ, Montell C (1999) . Activation of a TRPC3-dependent cation current through the neurotrophin BDNF. Neuron. 24 (1) : 261–73. 3. Zhou FW, Matta SG, Zhou FM (January 2008) . Constitutively active TRPC3 channels regulate basal ganglia output neurons. The Journal of Neuroscience. 28 (2) : 473–82.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

96009 MW

Applications Notes

6

Gene Name Synonym

Short transient receptor potential channel 3

Subcellular Location

Membrane; Multi-pass membrane protein.

Protein Name

Short transient receptor potential channel 3

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

TMEM176B (NM_001101314) Human Over-expression Lysate
LH05470V 100 µg

TMEM176B (NM_001101314) Human Over-expression Lysate

Ask
View Details
Recombinant Human ITPA Protein
E30P3902 20 µg

Recombinant Human ITPA Protein

Ask
View Details
GALNT3 (Polypeptide N-acetylgalactosaminyltransferase 3, Polypeptide GalNAc Transferase 3, GalNAc-T3, pp-GaNTase 3, Protein-UDP Acetylgalactosaminyltransferase 3, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3) (APC)
127138-APC 100 µL

GALNT3 (Polypeptide N-acetylgalactosaminyltransferase 3, Polypeptide GalNAc Transferase 3, GalNAc-T3, pp-GaNTase 3, Protein-UDP Acetylgalactosaminyltransferase 3, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3) (APC)

Ask
View Details
Human BPY2 knockdown cell line
ABC-KD1524 1 Vial

Human BPY2 knockdown cell line

Ask
View Details
Haptoglobin (HP) (NM_005143) Human Tagged ORF Clone Lentiviral Particle
RC223612L2V 200 µL

Haptoglobin (HP) (NM_005143) Human Tagged ORF Clone Lentiviral Particle

Ask
View Details
Her3 antibody (Tyr1328)
70R-37385 100 ug

Her3 antibody (Tyr1328)

Ask
View Details