Anti-BCMA/Tnfrsf17 Antibody Picoband®

B-cell maturation antigen (BCMA or BCM), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a protein that in humans is encoded by the TNFRSF17 gene. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.

A synthetic peptide corresponding to a sequence at the N-terminus of mouse BCMA/Tnfrsf17, which shares 78.9% and 95% amino acid (aa) sequence identity with human and rat BCMA/Tnfrsf17, respectively.

1. Entrez Gene: TNFRSF17 tumor necrosis factor receptor superfamily, member 17. 2. Laabi Y, Gras MP, Brouet JC, Berger R, Larsen CJ, Tsapis A (Apr 1994) . The BCMA gene, preferentially expressed during B lymphoid maturation, is biionally transcribed. Nucleic Acids Research. 22 (7) : 1147–54.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.