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Anti-PNN/DRSP Antibody Picoband®

Boster Bio Anti-PNN/DRSP Antibody Picoband® catalog # A01590-2. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Pinin is a protein that in humans is encoded by the PNN gene. By yeast 2-hybrid analysis of HeLa cells, followed by sequence analysis, it was found that epitope-tagged human PNN interacted with the serine/arginine (SR) -rich proteins SRP75 (SRSF4; 601940), SRM300 (SRRM2; 606032), and SRRP130 (PNISR; 616653) . Truncation analysis revealed that the polyserine/RS domain of PNN and flanking sequences participated in binding to these SR proteins. The 4 proteins colocalized in the nucleus of HCE-T cells, and overexpression of any of these proteins affected the distribution of the others between nuclear speckles and nucleoplasm.

Synonyms

Neutrophil cytosol factor 1; NCF-1; 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NCF-47K; Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox-organizing protein 2; SH3 and PX domain-containing protein 1A; p47-phox; NCF1; NOXO2; SH3PXD1A

Gene Name

PNN

Gene ID

5411

UniProt

Q9H307

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human PNN/DRSP recombinant protein (Position: A2-L241) .

Clonality

Polyclonal

Tissue Specificity

Detected in peripheral blood monocytes and neutrophils (at protein level) .

Applications

WB, Flow Cytometry, ELISA

Field of Research

Cancer, Cancer Metabolism, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production) .

References & Citations

1. Brandner, J. M., Reidenbach, S., Franke, W. W. Evidence that 'pinin, ' reportedly a differentiation-specific desmosomal protein, is actually a widespread nuclear protein. Differentiation 62: 119-127, 1997. 2. Brandner, J. M., Reidenbach, S., Kuhn, C., Franke, W. W. Identification and characterization of a novel kind of nuclear protein occurring free in nucleoplasm and in ribonucleoprotein structures of the 'speckle' type. Europ. J. Cell Biol. 75: 295-308, 1998. 3. Degen, W. G. J., Agterbos, M. A., Muyrers, J. P. P., Bloemers, H. P. J., Swart, G. W. M. memA/DRS, a putative mediator of multiprotein complexes, is overexpressed in the metastasizing human melanoma cell lines BLM and MV3. Biochim. Biophys. Acta 1444: 384-394, 1999.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

34140 MW

Observed Molecular Weight

82 kDa

Applications Notes

6

Gene Name Synonym

Neutrophil cytosolic factor 1

Subcellular Location

Cytoplasm, cytosol.

Protein Name

Growth/differentiation factor 15

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

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