Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-MCU Antibody Picoband®

Boster Bio Anti-MCU Antibody Picoband® catalog # A00685-1. Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

The mitochondrial calcium uniporter (MCU) is a transmembrane protein that allows the passage of calcium ions from a cell's cytosol into mitochondria. Its activity is regulated by MICU1 and MICU2, which together with the MCU make up the mitochondrial calcium uniporter complex. This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants.

Synonyms

Serine/threonine-protein kinase/endoribonuclease IRE1; Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; hIRE1p; Ire1-alpha; IRE1a; Serine/threonine-protein kinase; Endoribonuclease; ERN1

Gene Name

MCU

Gene ID

90550

UniProt

Q8NE86

Host

Rabbit

Reactivity

Human, Monkey, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human MCU recombinant protein (Position: V51-D351) .

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed. High levels observed in pancreatic tissue.

Applications

ELISA, Flow Cytometry, IHC, WB

Field of Research

Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.

References & Citations

1. Baughman, J. M., Perocchi, F., Girgis, H. S., Plovanich, M., Belcher-Timme, C. A., Sancak, Y., Bao, X. R., Strittmatter, L., Goldberger, O., Bagorad, R. L., Koteliansky, V., Mootha, V. K. Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Nature 476: 341-345, 2011. 2. De Stefani, D., Raffaello, A., Teardo, E., Szabo, I., Rizzuto, R. A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. Nature 476: 336-340, 2011. 3. Hartz, P. A. Personal Communication. Baltimore, Md. 8/31/2011.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A00685-1

Product MSDS

https://www.bosterbio.com/msds?sku=A00685-1

Calculated Molecular Weight

129383 MW

Observed Molecular Weight

34 kDa

Applications Notes

6

Gene Name Synonym

Endoplasmic reticulum to nucleus signaling 1

Subcellular Location

Endoplasmic reticulum membrane.

Protein Name

Thrombospondin-1

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Rat Nmnat2 Pre-designed siRNA Set B
SI209385B 1 Each

Rat Nmnat2 Pre-designed siRNA Set B

Ask
View Details
Zfp12 (NM_177681) Mouse Tagged ORF Clone
MG213812 10 µg

Zfp12 (NM_177681) Mouse Tagged ORF Clone

Ask
View Details
Rat PER2 (Period Circadian Protein 2) ELISA Kit
EK247451 96 Well

Rat PER2 (Period Circadian Protein 2) ELISA Kit

Ask
View Details
Mouse Cytochrome P450 3A4 (CYP3A4) ELISA Kit
MBS2604031-01 48 Well

Mouse Cytochrome P450 3A4 (CYP3A4) ELISA Kit

Ask
View Details
Mouse Cytochrome P450 3A4 (CYP3A4) ELISA Kit
MBS2604031-02 96 Well

Mouse Cytochrome P450 3A4 (CYP3A4) ELISA Kit

Ask
View Details
Mouse Cytochrome P450 3A4 (CYP3A4) ELISA Kit
MBS2604031-03 5x 96 Well

Mouse Cytochrome P450 3A4 (CYP3A4) ELISA Kit

Ask
View Details