Anti-FOXP1 Antibody Picoband® Fluoro488 Conjugated

FOXP1 (forkhead box P1) is a gene that is necessary for the proper development of the brain and lung in mammals. It is a member of the large FOX family of transcription factors. This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene (s) . Alternative splicing results in multiple transcript variants encoding different isoforms. It was shown that the embryonic stem cell (ESC) -specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency, including OCT4, NANOG, NR5A2, and GDF3, while concomitantly repressing genes required for ESC differentiation. This isoform also promotes the maintenance of ESC pluripotency and contributes to efficient reprogramming of somatic cells into induced pluripotent stem cells. These results reveal a pivotal role for an Alternative splicing event in the regulation of pluripotency through the control of critical ESC-specific transcriptional programs (2) .

May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.

1. Banham, A. H., Beasley, N., Campo, E., Fernandez, P. L., Fidler, C., Gatter, K., Jones, M., Mason, D. Y., Prime, J. E., Trougouboff, P., Wood, K., Cordell, J. L.The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p.Cancer Res. 61: 8820-8829, 2001. 2. Feng, X., Ippolito, G. C., Tian, L., Wiehagen, K., Oh, S., Sambandam, A., Willen, J., Bunte, R. M., Maika, S. D., Harriss, J. V., Caton, A. J., Bhandoola, A., Tucker, P. W., Hu, H.Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development.Blood 115: 510-518, 2010. 3. Shi, C., Sakuma, M., Mooroka, T., Liscoe, A., Gao, H., Croce, K. J., Sharma, A., Kaplan, D., Greaves, D. R., Wang, Y., Simon, D. I.Down-regulation of the forkhead transcription factor Foxp1 is required for monocyte differentiation and macrophage function.Blood 112: 4699-4711, 2008.