Anti-LOC134147/CMBL Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
CMBL is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the medoxomil moiety is linked to an oxygen atom.
Synonyms
Meiotic recombination protein REC8 homolog; Cohesin Rec8p; REC8; REC8L1
Gene Name
Cmbl
Gene ID
69574
UniProt
Q8R1G2
Host
Rabbit
Reactivity
Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of mouse LOC134147/CMBL, which shares 88.2% and 94.1% amino acid (aa) sequence identity with human and rat LOC134147/CMBL, respectively.
Clonality
Polyclonal
Tissue Specificity
Expressed in testis and thymus. Expressed in the B-cell lines WI-L2-NS and Namalwa.
Applications
Flow Cytometry
Field of Research
Vasculature
Purification
Immunogen affinity purified.
Form
Liquid
Function
Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II.
References & Citations
1. Ishizuka, T., Fujimori, I., Kato, M., Noji-Sakikawa, C., Saito, M., Yoshigae, Y., Kubota, K., Kurihara, A., Izumi, T., Ikeda, T., Okazaki, O. Human carboxymethylenebutenolidase as a bioactivating hydrolase of olmesartan medoxomil in liver and intestine. J. Biol. Chem. 285: 11892-11902, 2010.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
56903 MW
Applications Notes
6
Gene Name Synonym
REC8 meiotic recombination protein
Subcellular Location
Nucleus. Chromosome. Centromere.
Protein Name
Vesicular acetylcholine transporter
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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