Anti-UNG Antibody Picoband®

Uracil-DNA glycosylase, also known as UNG or UDG, is a human gene though orthologs exist ubiquitously among prokaryotes and eukaryotes and even in some DNA viruses. The first uracil DNA-glycosylase was isolated from Escherichia coli. This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene, which has been confused with this gene, in the literature and some databases.

Phosphatidylethanolamine-binding protein 1; PEBP-1; HCNPpp; Neuropolypeptide h3; Prostatic-binding protein; Raf kinase inhibitor protein; RKIP; Hippocampal cholinergic neurostimulating peptide; HCNP; PEBP1; PBP; PEBP

Epigenetics and Nuclear Signaling, Cancer, Cell Biology, Oncoproteins/Suppressors, Tumor Suppressors, Cell Cycle, Neuroscience, Cell Division, Kinases/Phosphatases, Spindle, Neurotransmitter, Neuropeptides

Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity) . Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation.

1. Lindahl T, Ljungquist S, Siegert W, Nyberg B, Sperens B (May 1977) . DNA N-glycosidases: properties of uracil-DNA glycosidase from Escherichia coli. The Journal of Biological Chemistry. 252 (10) : 3286–94. 2. Longo MC, Berninger MS, Hartley JL (Sep 1990) . Use of uracil DNA glycosylase to control carry-over contamination in polymerase chain reactions. Gene. 93 (1) : 125–8. 3. Pearl LH (Aug 2000) . Structure and function in the uracil-DNA glycosylase superfamily. Mutation Research. 460 (3-4) : 165–81.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.