Anti-Tubulin beta Antibody Picoband®

TUBB1 is a gene that codes for the protein Tubulin beta-1 chain in humans. This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y.

RNA binding protein fox-1 homolog 2; Fox-1 homolog B; Hexaribonucleotide-binding protein 2; RNA-binding motif protein 9; RNA-binding protein 9; Repressor of tamoxifen transcriptional activity; RBFOX2; FOX2; HRNBP2; RBM9; RTA

Expressed in fetal brain. Highly expressed in brain and placenta. Lower levels in heart, liver, thymus, kidney and lung. Located to endothelial cells and neuronal cells of the suprachiasmatic nucleus (SCN) . Also detected in endothelial cells of the heart, lung and kidney. In the brain, specifically expressed in the thalamus, hippocampus and amygdala.

Cardiogenesis, Cardiovascular, Domain Families, Epigenetics and Nuclear Signaling, Hlh/Leucine Zipper, Neurology Process, Neuroscience, Receptors, Transcription, Transcription Factors, Transcription Factors/Regulators

RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity) . RNA-binding protein that seems to act as a coregulatory factor of ER-alpha.

1. Davis, B., Toivio-Kinnucan, M., Schuller, S., Boudreaux, M. K. Mutation in beta-1-tubulin correlates with macrothrombocytopenia in Cavalier King Charles Spaniels. J. Vet. Intern. Med. 22: 540-545, 2008. 2. Freson, K., De Vos, R., Wittevrongel, C., Thys, C., Defoor, J., Vanhees, L., Vermylen, J., Peerlinck, K., Van Geet, C. The TUBB1 Q43P functional polymorphism reduces the risk of cardiovascular disease in men by modulating platelet function and structure. Blood 106: 2356-2362, 2005. 3. Kunishima, S., Kobayashi, R., Itoh, T. J., Hamaguchi, M., Saito, H. Mutation of the beta-1-tubulin gene associated with congenital macrothrombocytopenia affecting microtubule assembly. Blood 113: 458-461, 2009.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.