Anti-CD30/TNFRSF8 Antibody Picoband® Fluoro488 Conjugated

CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. It is mapped to 4 E1; 4 78.17 cM. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Ubiquitous expression with high levels in trabecular bone, thymus, small intestine, lung, brain and kidney. Weakly expressed in spleen and bone marrow.

Alzheimer's Disease, Apoptosis, Associated Proteins, Cancer, Cancer Susceptibility, Cell Biology, Epigenetics and Nuclear Signaling, Growth Factors, Intracellular, Neurodegenerative Disease, Neurology Process, Neuroscience, Oncoproteins/Suppressors, p53 Pathway, Transcription, Tumor Suppressors

Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.

1. Fischer, M., Harvima, I. T., Carvalho, R. F. S., Moller, C., Naukkarinen, A., Enblad, G., Nilsson, G. Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion. J. Clin. Invest. 116: 2748-2756, 2006. 2. Gorczyca W, Tsang P, Liu Z, et al. (February 2003) . CD30-positive T-cell lymphomas co-expressing CD15: an immunohistochemical analysis. Int. J. Oncol. 22 (2) : 319–24. 3. Teng LH, Lu DH, Xu QZ, Fu YJ, Yang H, He ZL (2005) . [Expression and diagnostic significance of OCT4, CD117 and CD30 in germ cell tumors]. Zhonghua Bing Li Xue Za Zhi (in Chinese) 34 (11) : 711–5.