Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-GRB14 Antibody Picoband® Fluoro550 Conjugated

Product Specifications

Background

Growth factor receptor-bound protein 14 is a protein that in humans is encoded by the GRB14 gene. The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants.

Synonyms

Endothelial cell-specific molecule 1; ESM-1; ESM1

Gene Name

GRB14

Gene ID

2888

UniProt

Q14449

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human GRB14 recombinant protein (Position: M1-Q246) .

Clonality

Polyclonal

Tissue Specificity

Expressed in lung, on the vascular capillary network within alveolar walls, and also at lower level in kidney.

Applications

Flow Cytometry

Field of Research

Cell Type Markers, Tags & Cell Markers

Purification

Immunogen affinity purified.

Form

Liquid

Function

Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions.

References & Citations

1. Daly, R. J., Sanderson, G. M., Janes, P. W., Sutherland, R. L. Cloning and characterization of GRB14, a novel member of the GRB7 gene family. J. Biol. Chem. 271: 12502-12510, 1996. 2. Depetris, R. S., Hu, J., Gimpelevich, I., Holt, L. J., Daly, R. J., Hubbard, S. R. Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14. Molec. Cell 20: 325-333, 2005. 3. Dong, L. Q., Du, H., Porter, S. G., Kolakowski, L. F., Jr., Lee, A. V., Mandarino, L. J., Fan, J., Yee, D., Liu, F. Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10-gamma. J. Biol. Chem. 272: 29104-29112, 1997. Note: Erratum: J. Biol. Chem. 273: 4288 only, 1998.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

Endothelial cell specific molecule 1

Subcellular Location

Secreted.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

ATXN7L1 (NM_152749) Human Tagged ORF Clone
RC206079 10 µg

ATXN7L1 (NM_152749) Human Tagged ORF Clone

Ask
View Details
50bp DNA Ladder
M1800-01 50 Tests

50bp DNA Ladder

Ask
View Details
50bp DNA Ladder
M1800-02 100 Tests

50bp DNA Ladder

Ask
View Details
Human T-cell immunomodulatory protein (ITFG1) ELISA Kit
EIA06741h 1 Kit

Human T-cell immunomodulatory protein (ITFG1) ELISA Kit

Ask
View Details
RPS15AP31 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
42130061 1.0 µg DNA

RPS15AP31 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

Ask
View Details
mmu-miR-297c-5p miRNA Inhibitor
MBS8295889-01 10 nmol

mmu-miR-297c-5p miRNA Inhibitor

Ask
View Details