Anti-FUT4 Antibody Picoband®

Fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific), also known as FUT4, is an enzyme which in humans is encoded by the FUT4 gene. The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15) .

A synthetic peptide corresponding to a sequence at the C-terminus of human FUT4, which shares 72.7% and 71.4% amino acid (aa) sequence identity with mouse and rat FUT4, respectively.

Angiogenesis, Cancer, Cardiovascular, Growth Factors, Growth Factors/Hormones, Invasion/Microenvironment, Neurogenesis, Neurology Process, Neuroscience, Signal Transduction

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors ly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.

1. Cailleau-Thomas, A., Coullin, P., Candelier, J.-J., Balanzino, L., Mennesson, B., Oriol, R., Mollicone, R. FUT4 and FUT9 genes are expressed early in human embryogenesis. Glycobiology 10: 789-802, 2000. 2. Couillin, P., Mollicone, R., Grisard, M. C., Gibaud, A., Ravise, N., Feingold, J., Oriol, R. Chromosome 11q localization of one of the three expected genes for the human alpha-3-fucosyltransferases, by somatic hybridization. Cytogenet. Cell Genet. 56: 108-111, 1991. 3. Gersten, K. M., Natsuka, S., Trinchera, M., Petryniak, B., Kelly, R. J., Hiraiwa, N., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., Lowe, J. B. Molecular cloning, expression, chromosomal assignment, and tissue-specific expression of a murine alpha- (1,3) -fucosyltransferase locus corresponding to the human ELAM-1 ligand fucosyl transferase. J. Biol. Chem. 270: 25047-25056, 1995.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.