Anti-MitoNEET/CISD1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
CISD1 is a member of the CDGSH domain-containing family and may play a role in the regulation of mitochondrial oxidative capacity. This gene encodes a protein with a CDGSH iron-sulfur domain and has been shown to bind a redox-active [2Fe-2S] cluster. The encoded protein has been localized to the outer membrane of mitochondria. Genes encoding similar proteins are located on chromosomes 4 and 17, and a pseudogene of this gene is located on chromosome 2.
Synonyms
Urokinase-type plasminogen activator; U-plasminogen activator; uPA; Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B; PLAU
Gene Name
CISD1
Gene ID
55847
UniProt
Q9NZ45
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human MitoNEET/CISD1 recombinant protein (Position: Y28-E93) .
Clonality
Polyclonal
Tissue Specificity
Expressed in the prostate gland and prostate cancers.
Applications
Flow Cytometry
Field of Research
Adaptive Immunity, B Cells, Hematopoietic Progenitors, Immunoglobulins, Immunology, Lymphoid, Receptors, Stem Cells
Purification
Immunogen affinity purified.
Form
Liquid
Function
Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
References & Citations
1. Colca, J. R., McDonald, W. G., Waldon, D. J., Leone, J. W., Lull, J. M., Bannow, C. A., Lund, E. T., Mathews, W. R. Identification of a novel mitochondrial protein ('mitoNEET') cross-linked specifically by a thiazolidinedione photoprobe. Am. J. Physiol. Endocr. Metab. 286: E252-60, 2004. 2. Hou, X., Liu, R., Ross, S., Smart, E. J., Zhu, H., Gong, W. Crystallographic studies of human MitoNEET. J. Biol. Chem. 282: 33242-33246, 2007. 3. Lin, J., Zhou, T., Ye, K., Wang, J. Crystal structure of human mitoNEET reveals distinct groups of iron-sulfur proteins. Proc. Nat. Acad. Sci. 104: 14640-14645, 2007.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Plasminogen activator, urokinase
Subcellular Location
Secreted.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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