Anti-C5a-R/C5ar1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
The C5a receptor also known as complement component 5a receptor 1 (C5AR1) or CD88 (Cluster of Differentiation 88) is a G protein-coupled receptor for C5a. It functions as a complement receptor. C5a receptor modulates inflammatory responses, obesity, development and cancers.
Synonyms
C-C chemokine receptor type 1; C-C CKR-1; CC-CKR-1; CCR-1; CCR1; Macrophage inflammatory protein 1-alpha receptor; MIP-1alpha-R; RANTES-R; CD191; Ccr1; Cmkbr1
Gene Name
C5ar1
Gene ID
12273
UniProt
P30993
Host
Rabbit
Reactivity
Mouse
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived mouse C5a-R/C5ar1 recombinant protein (Position: H29-D327) .
Clonality
Polyclonal
Tissue Specificity
Detected in the heart, spleen, lung, peritoneal exudate cells and leukocytes.
Applications
Flow Cytometry
Field of Research
Chemokines, Immunology, Innate Immunity
Purification
Immunogen affinity purified.
Form
Liquid
Function
Receptor for a C-C type chemokine. Binds to MIP-1-alpha, RANTES, and less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.
References & Citations
1. Arbore, G., West, E. E., Spolski, R., Robertson, A. A. B., Klos, A., Rheinheimer, C., Dutow, P., Woodruff, T. M., Yu, Z. X., O'Neill, L. A., Coll, R. C., Sher, A., and 10 others. T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells. Science 352: aad1210, 2016 2. Atkinson, J. P. Complement system on the attack in autoimmunity. (Commentary) J. Clin. Invest. 112: 1639-1641, 2003. 3. Bao, L., Gerard, N. P., Eddy, R. L., Jr., Shows, T. B., Gerard, C. Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19. Genomics 13: 437-440, 1992.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
40895 MW
Applications Notes
6
Gene Name Synonym
C-C chemokine receptor type 1
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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