Anti-ALDH1L1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
10-formyltetrahydrofolate dehydrogenase is an enzyme that in humans is encoded by the ALDH1L1 gene. The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, NADP, and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family and is responsible for formate oxidation in vivo. Deficiencies in this gene can result in an accumulation of formate and subsequent methanol poisoning.
Synonyms
Type I iodothyronine deiodinase; 5DI; DIOI; Type 1 DI; Type-I 5'-deiodinase; DIO1; ITDI1; TXDI1
Gene Name
ALDH1L1
Gene ID
10840
UniProt
O75891
Host
Rabbit
Reactivity
Human, Mouse, Rat, Monkey
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human ALDH1L1 recombinant protein (Position: N282-L424) .
Clonality
Polyclonal
Tissue Specificity
Widely expressed in adult (at protein level) and fetal tissues.
Applications
Flow Cytometry
Field of Research
Cancer, Oncoproteins/Suppressors, Tumor Suppressors
Purification
Immunogen affinity purified.
Form
Liquid
Function
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine) . Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney.
References & Citations
1. Champion, K. M., Cook, R. J., Tollaksen, S. L., Giometti, C. S. Identification of a heritable deficiency of the folate-dependent enzyme 10-formyltetrahydrofolate dehydrogenase in mice. Proc. Nat. Acad. Sci. 91: 11338-11342, 1994. 2. Gross, M. B. Personal Communication. Baltimore, Md. 11/2/2010. 3. Hong, M., Lee, Y., Kim, J. W., Lim, J. S., Chang, S. Y., Lee, K. S., Paik, S. G., Choe, I. S. Isolation and characterization of cDNA clone for human liver 10-formyltetrahydrofolate dehydrogenase. Biochem. Molec. Biol. Int. 47: 407-415, 1999.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Iodothyronine deiodinase 1
Subcellular Location
Endoplasmic reticulum membrane. Single-pass membrane protein.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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