Anti-Wnt8a Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and may be implicated in development of early embryos as well as germ cell tumors. Multiple alternatively spliced transcript variants have been found for this gene.
Synonyms
Disintegrin and metalloproteinase domain-containing protein 2; ADAM 2; Cancer/testis antigen 15; CT15; Fertilin subunit beta; PH-30; PH30; PH30-beta; ADAM2; FTNB
Gene Name
WNT8A
Gene ID
7478
UniProt
Q9H1J5
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human Wnt8a recombinant protein (Position: D206-S339) .
Clonality
Polyclonal
Tissue Specificity
Expressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal tissues.
Applications
Flow Cytometry
Field of Research
Cancer, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.
References & Citations
1. Janda, C. Y., Waghray, D., Levin, A. M., Thomas, C., Garcia, K. C. Structural basis of Wnt recognition by frizzled. Science 337: 59-64, 2012. 2. Saitoh, T., Katoh, M. Molecular cloning and characterization of human WNT8A. Int. J. Oncol. 19: 123-127, 2001. 3. Smith, J., Theodoris, C., Davidson, E. H. A gene regulatory network subcircuit drives a dynamic pattern of gene expression. Science 318: 794-797, 2007.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
82457 MW
Applications Notes
6
Gene Name Synonym
Disintegrin and metalloproteinase domain-containing protein 2
Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Name
Disintegrin and metalloproteinase domain-containing protein 2
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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