Anti-Neurotrophin 3/NTF3 Antibody Picoband® Fluoro647 Conjugated

The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse.

A synthetic peptide corresponding to a sequence at the C-terminus of human Neurotrophin 3/NTF3, which shares 89.3% and 95.3% amino acid (aa) sequence identity with mouse and rat Neurotrophin 3/NTF3, respectively.

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.

1. Kalcheim, C., Carmeli, C., Rosenthal, A. Neurotrophin 3 is a mitogen for cultured neural crest cells. Proc. Nat. Acad. Sci. 89: 1661-1665, 1992. 2. Ma, L., Harada, T., Harada, C., Romero, M., Hebert, J. M., McConnell, S. K., Parada, L. F. Neurotrophin-3 is required for appropriate establishment of thalamocortical connections. Neuron 36: 623-634, 2002. 3. Ozcelik, T., Rosenthal, A., Francke, U. Chromosomal mapping of brain-derived neurotrophic factor and neurotrophin-3 genes in man and mouse. Genomics 10: 569-575, 1991.