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Anti-CD73/Nt5e Antibody Picoband® Fluoro550 Conjugated

Product Specifications

Background

The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.

Synonyms

Carnitine O-palmitoyltransferase 2, mitochondrial; Carnitine palmitoyltransferase II; CPT II; CPT2; CPT1

Gene Name

Nt5e

Gene ID

23959

UniProt

Q61503

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived mouse CD73/Nt5e recombinant protein (Position: S337-S551) .

Clonality

Polyclonal

Tissue Specificity

Expressed mainly in adipose tissues.

Applications

Flow Cytometry

Field of Research

Cardiovascular, G Protein Signaling, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Form

Liquid

Function

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.

References & Citations

1. Boyle, J. M., Hey, Y., Fox, M. Human ecto-5-prime nucleotidase maps to chromosome 6q14-q21. (Abstract) Cytogenet. Cell Genet. 51: 968 only, 1989. 2. Castrop, H., Huang, Y., Hashimoto, S., Mizel, D., Hansen, P., Theilig, F., Bachmann, S., Deng, C., Briggs, J., Schnermann, J. Impairment of tubuloglomerular feedback regulation of GFR in ecto-5-prime-nucleotidase/CD73-deficient mice. J. Clin. Invest. 114: 634-642, 2004. 3. St. Hilaire, C., Ziegler, S. G., Markello, T. C., Brusco, A., Groden, C., Gill, F., Carlson-Donohoe, H., Lederman, R. J., Chen, M. Y., Yang, D., Siegenthaler, M. P., Arduino, C., and 9 others. NT5E mutations and arterial calcifications. New Eng. J. Med. 364: 432-442, 2011.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

51990 MW

Applications Notes

6

Gene Name Synonym

Carnitine palmitoyltransferase 2

Subcellular Location

Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side

Protein Name

Angiotensinogen

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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