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Anti-Glypican 5/GPC5 Antibody Picoband® Fluoro647 Conjugated

Selected Variant

A07532-1-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.

Synonyms

Formin-1; Limb deformity protein homolog; FMN1; FMN, LD

Gene Name

GPC5

Gene ID

2262

UniProt

P78333

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Glypican 5/GPC5 recombinant protein (Position: Q28-D538) .

Clonality

Polyclonal

Tissue Specificity

Expressed ubiquitously.

Applications

Flow Cytometry

Field of Research

Actin Assembly, Actin, etc., Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Plays a role in the formation of adherens junction and the polymerization of linear actin cables. .

References & Citations

1. Neat, M. J., Foot, N., Jenner, M., Goff, L., Ashcroft, K., Burford, D., Dunham, A., Norton, A., Lister, T. A., Fitzgibbon, J. Localisation of a novel region of recurrent amplification in follicular lymphoma to an ~6.8 Mb region of 13q32-33. Genes Chromosomes Cancer 32: 236-243, 2001. 2. Veugelers, M., Vermeesch, J., Reekmans, G., Steinfeld, R., Marynen, P., David, G. Characterization of glypican-5 and chromosomal localization of human GPC5, a new member of the glypican gene family. Genomics 40: 24-30, 1997. 3. Yu, W., Inoue, J., Imoto, I., Matsuo, Y., Karpas, A., Inazawa, J. GPC5 is a possible target for the 13q31-q32 amplification detected in lymphoma cell lines. J. Hum. Genet. 48: 331-335, 2003.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

157578 MW

Applications Notes

6

Gene Name Synonym

Formin-1

Subcellular Location

Nucleus . Cytoplasm . Cell junction, adherens junction . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Localization to the adherens junctions is alpha-catenin-dependent. Also localizes to F-actin bundles originating from adherens junctions and to microtubules (By similarity) . .

Protein Name

BAG family molecular chaperone regulator 5

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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