Anti-GATA3 Antibody Picoband®

Trans-acting T-cell-specific transcription factor GATA-3, also named HDR or GATA3, is a protein that in humans is encoded by the GATA3 gene. It is mapped to 10p14. This gene belongs to the GATA family of transcription factors. It regulates luminal epithelial cell differentiation in the mammary gland. The protein contains two GATA-type zinc fingers, it is an important regulator of T cell development and plays an important role in endothelial cell biology. GATA3 has been shown to promote the secretion of IL-4, IL-5, and IL-13 from Th2 cells, and induces the differentiation of Th0 cells towards this T cell subtype while suppressing their differentiation towards Th1 cells.

A synthetic peptide corresponding to a sequence at the N-terminus of human GATA3, which shares 86.4% and 90.9% amino acid (aa) sequence identity with mouse and rat GATA3, respectively.

ATPases, Cancer, Metabolism, Neuroscience, Neurotransmission, Plasma Membrane, Protein Trafficking, Secretory Vesicles, Signal Transduction, Vesicle Transport

Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity) .

1. Joulin V, Bories D, Eleouet JF, Labastie MC, Chretien S, Mattei MG, Romeo PH (Jul 1991) . A T-cell specific TCR delta DNA binding protein is a member of the human GATA family 2. Kouros-Mehr Hosein, Slorach EM, Sternlicht MD, Werb Z (December 2006) . GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland. Cell 127 (5) : 1041–55. 3. Wilson BJ (2008) . Does GATA3 act in tissue-specific pathways? A meta-analysis-based approach. J. Carcinogenesis 7: 6.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.