Anti-Endothelin A Receptor/ET-A/EDNRA Antibody Picoband® Fluoro647 Conjugated

This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants.

Detected adjacent to nodes of Ranvier in juxtaparanodal zones in spinal cord nerve fibers, but also in paranodal regions in some myelinated spinal cord axons (at protein level) (PubMed:11086297) . Detected in the islet of Langerhans (PubMed:21483673) .

1. Bourgeois, C., Robert, B., Rebourcet, R., Mondon, F., Mignot, T.-M., Duc-Goiran, P., Ferre, F. Endothelin-1 and ET (A) receptor expression in vascular smooth muscle cells from human placenta: a new ET (A) receptor messenger ribonucleic acid is generated by alternative splicing of exon 3. J. Clin. Endocr. Metab. 82: 3116-3123, 1997. 2. Campia, U., Cardillo, C., Panza, J. A. Ethnic differences in the vasoconstrictor activity of endogenous endothelin-1 in hypertensive patients. Circulation 109: 3191-3195, 2004. 3. Charite, J., McFadden, D. G., Merlo, G., Levi, G., Clouthier, D. E., Yanagisawa, M., Richardson, J. A., Olson, E. N. Role of Dlx6 in regulation of an endothelin-1-dependent dHAND branchial arch enhancer. Genes Dev. 15: 3039-3049, 2001.