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Anti-DLL1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. This gene is mapped to chromosome 6q27.

Synonyms

Tumor necrosis factor receptor superfamily member 4; MRC OX40; OX40 antigen; OX40L receptor; CD134; Tnfrsf4; Ox40; Txgp1l

Gene Name

DLL1

Gene ID

28514

UniProt

O00548

Host

Rabbit

Reactivity

Human, Monkey, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human DLL1 recombinant protein (Position: Q18-K239) .

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

Adaptive Immunity, Autoimmune, B Cells, Cytokines, Hematopoietic Progenitors, Immune System Diseases, Immunology, Innate Immunity, Lymphoid, Stem Cells, T Cells, T Lymphocytic Lineage, TNF Superfamily

Purification

Immunogen affinity purified.

Form

Liquid

Function

Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity (By similarity) . .

References & Citations

1. Chakrabarti, R., Celia-Terrassa, T., Kumar, S., Hang, X., Wei, Y., Choudhury, A., Hwang, J., Peng, J., Nixon, B., Grady, J. J., DeCoste, C., Gao, J., van Es, J. H., Li, M. O., Aifantis, I., Clevers, H., Kang, Y. Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche. Science 360: 1421 only, 2018. Note: Full Article Online. 2. Fischer-Zirnsak, B., Segebrecht, L., Schubach, M., Charles, P., Alderman, E., Brown, K., Cadieux-Dion, M., Cartwright, T., Chen, Y., Costin, C., Fehr, S., Fitzgerald, K. M., and 26 others. Haploinsufficiency of the Notch ligand DLL1 causes variable neurodevelopmental disorders. Am. J. Hum. Genet. 105: 631-639, 2019.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

TNF receptor superfamily member 4

Subcellular Location

Membrane; Single-pass type I membrane protein.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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