Anti-Cyt 19/As3mt Antibody Picoband® Fluoro647 Conjugated

AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism. This gene is mapped to chromosome 10q24.

Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.

1. Hernandez, A., Xamena, N., Sekaran, C., Tokunaga, H., Sampayo-Reyes, A., Quinteros, D., Creus, A., Marcos, R. High arsenic metabolic efficiency in AS3MT-287Thr allele carriers. Pharmacogenet. Genomics 18: 349-355, 2008. 2. Lin, S., Shi, Q., Nix, F. B., Styblo, M., Beck, M. A., Herbin-Davis, K. M., Hall, L. L., Simeonsson, J. B., Thomas, D. J. A novel S-adenosyl-L-methionine:arsenic (III) methyltransferase from rat liver cytosol. J. Biol. Chem. 277: 10795-10803, 2002. 3. Wood, T. C., Salavagionne, O. E., Mukherjee, B., Wang, L., Klumpp, A. F., Thomae, B. A., Eckloff, B. W., Schaid, D. J., Wieben, E. D., Weinshilboum, R. M. Human arsenic methyltransferase (AS3MT) pharmacogenetics: Gene resequencing and functional genomics studies. J. Biol. Chem. 281: 7364-7373, 2006.