Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Vinexin/SORBS3 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Vinexin is a protein that in humans is encoded by the SORBS3 gene. It is mapped to 8p21.3. This gene encodes an SH3 domain-containing adaptor protein. The presence of SH3 domains play a role in this protein's ability to bind other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms

Vinexin; SH3-containing adapter molecule 1; SCAM-1; Sorbin and SH3 domain-containing protein 3; SORBS3; SCAM1

Gene Name

SORBS3

Gene ID

10174

UniProt

O60504

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human Vinexin/SORBS3, which shares 87.5% and 84.4% amino acid (aa) sequence identity with mouse and rat Vinexin/SORBS3, respectively.

Clonality

Polyclonal

Tissue Specificity

Both isoforms are expressed in different tissues like heart, placenta, brain, skeletal muscle and pancreas. Isoform beta is especially found in liver.

Applications

Flow Cytometry

Field of Research

Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.

References & Citations

1. Kioka, N., Sakata, S., Kawauchi, T., Amachi, T., Akiyama, S. K., Okazaki, K., Yaen, C., Yamada, K. M., Aota, S. Vinexin: a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization. J. Cell Biol. 144: 59-69, 1999. 2. Mitsushima, M., Ueda, K., Kioka, N. Vinexin-beta regulates the phosphorylation of epidermal growth factor receptor on the cell surface. Genes Cells 11: 971-982, 2006. 3. Suwa, A., Mitsushima, M., Ito, T., Akamatsu, M., Ueda, K., Amachi, T., Kioka, N. Vinexin-beta regulates the anchorage dependence of ERK2 activation stimulated by epidermal growth factor. J. Biol. Chem. 277: 13053-13058, 2002.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

16693 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Sorbin and SH3 domain containing 3

Subcellular Location

Cytoskeleton. Cell junction. Nucleus. Cytoskeleton. Cell junction.

Protein Name

Protein phosphatase 1 regulatory subunit 14A

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

More Discoveries

Explore Other Products

Browse additional items from our catalog

SLC39A8 Protein Vector (Rat) (pPM-C-HA)
PV306120 500 ng

SLC39A8 Protein Vector (Rat) (pPM-C-HA)

Sign In for Pricing
View Details
BRAP Recombinant Protein Antigen
NBP1-91705PEP 0.1 mL

BRAP Recombinant Protein Antigen

Sign In for Pricing
View Details
SOX13 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)
K2261206 1.0 µg DNA

SOX13 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)

Sign In for Pricing
View Details
CYP2D8P1 3'UTR GFP Stable Cell Line
TU055460 1.0 mL

CYP2D8P1 3'UTR GFP Stable Cell Line

Sign In for Pricing
View Details
Rabbit Polyclonal PDE3B Antibody [Alexa Fluor 350]
NBP1-46183AF350 0.1 mL

Rabbit Polyclonal PDE3B Antibody [Alexa Fluor 350]

Sign In for Pricing
View Details
ASB6 (Ankyrin Repeat and SOCS Box Protein 6, ASB-6, FLJ20548, MGC1024)
123602 50 µg

ASB6 (Ankyrin Repeat and SOCS Box Protein 6, ASB-6, FLJ20548, MGC1024)

Sign In for Pricing
View Details