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Anti-RBPMS Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

RNA-binding protein with multiple splicing is a protein that in humans is encoded by the RBPMS gene. It is mapped to 8p12. This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif is between 80-100 amino acids in length and family members contain one to four copies of the motif. The RNA recognition motif consists of two short stretches of conserved sequence, as well as a few highly conserved hydrophobic residues. The encoded protein has a single, putative RNA recognition motif in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms.

Synonyms

RNA-binding protein with multiple splicing; RBP-MS; Heart and RRM expressed sequence; Hermes; RBPMS; HERMES

Gene Name

RBPMS

Gene ID

11030

UniProt

Q93062

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human RBPMS recombinant protein (Position: K6-C196) .

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed, at various levels depending on the isoform and the tissue.

Applications

Flow Cytometry

Field of Research

Cancer, DNA/RNA, Epigenetics and Nuclear Signaling, Ribosome, Translation, Tumor Biomarkers

Purification

Immunogen affinity purified.

Form

Liquid

Function

Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly (A) RNA.

References & Citations

1. Lim, J., Hao, T., Shaw, C., Patel, A. J., Szabo, G., Rual, J.-F., Fisk, C. J., Li, N., Smolyar, A., Hill, D. E., Barabasi, A.-L., Vidal, M., Zoghbi, H. Y. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Cell 125: 801-814, 2006. 2. Shimamoto, A., Kitao, S., Ichikawa, K., Suzuki, N., Yamabe, Y., Imamura, O., Tokutake, Y., Satoh, M., Matsumoto, T., Kuromitsu, J., Kataoka, H., Sugawara, K., Sugawara, M., Sugimoto, M., Goto, M., Furuichi, Y. A unique human gene that spans over 230 kb in the human chromosome 8p11-12 and codes multiple family proteins sharing RNA-binding motifs. Proc. Nat. Acad. Sci. 93: 10913-10917, 1996.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

RNA binding protein, mRNA processing factor

Subcellular Location

Nucleus. Cytoplasm. P-body.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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