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Anti-PRDM5 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

PR domain zinc finger protein 5 is a protein that in humans is encoded by the PRDM5 gene. It is mapped to 4q27. The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis.

Synonyms

PR domain zinc finger protein 5; PR domain-containing protein 5; PRDM5; PFM2

Gene Name

PRDM5

Gene ID

11107

UniProt

Q9NQX1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human PRDM5 recombinant protein (Position: Y24-S630) .

Clonality

Polyclonal

Tissue Specificity

Widely expressed with highest levels in colon and ovary. Tends to be silenced in breast, colorectal, gastric and liver cancer tissues.

Applications

Flow Cytometry

Field of Research

Cell Adhesion Proteins, ECM Proteins, Neuroscience

Purification

Immunogen affinity purified.

Form

Liquid

Function

Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May cause G2/M arrest and apoptosis in cancer cells.

References & Citations

1. Aldahmesh, M. A., Mohamed, J. Y., Alkuraya, F. S. A novel mutation in PRDM5 in brittle cornea syndrome. (Letter) Clin. Genet. 81: 198-199, 2012. 2. Burkitt Wright, E. M. M., Spencer, H. L., Daly, S. B., Manson, F. D. C., Zeef, L. A. H., Urquhart, J., Zoppi, N., Bonshek, R., Tosounidis, I., Mohan, M., Madden, C., Dodds, A., and 11 others. Mutations in PRDM5 in brittle cornea syndrome identify a pathway regulating extracellular matrix development and maintenance. Am. J. Hum. Genet. 88: 767-777, 2011. Note: Erratum: Am. J. Hum. Genet. 89: 346 only, 2011. 3. Deng, Q., Huang, S. PRDM5 is silenced in human cancers and has growth suppressive activities. Oncogene 23: 4903-4910, 2004.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

104553 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

PR/SET domain 5

Subcellular Location

Nucleus.

Protein Name

AP-2 complex subunit beta

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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