Anti-NFIC/CTF Antibody Picoband® Fluoro647 Conjugated

Nuclear factor 1 C-type is a protein that in humans is encoded by the NFIC gene. It is mapped to 19p13.3. The protein encoded by this gene belongs to the CTF/NF-I family. These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for adenovirus DNA replication. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Nuclear factor 1 C-type; NF1-C; Nuclear factor 1/C; CCAAT-box-binding transcription factor; CTF; Nuclear factor I/C; NF-I/C; NFI-C; TGGCA-binding protein; NFIC; NFI

Mainly expressed in testis. Isoform 3 is expressed predominantly in adult testis, weakly in pancreas, embryonic testis and sperm, and at very low levels in other organs.

Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

1. Grunder, A., Qian, F., Ebel, T. T., Mincheva, A., Lichter, P., Kruse, U., Sippel, A. E. Genomic organization, splice products and mouse chromosomal localization of genes for transcription factor nuclear factor one. Gene 304: 171-181, 2003. 2. Qian, F., Kruse, U., Lichter, P., Sippel, A. E. Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH. Genomics 28: 66-73, 1995. 3. Steele-Perkins, G., Butz, K. G., Lyons, G. E., Zeichner-David, M., Kim, H.-J., Cho, M.-I., Gronostajski, R. M. Essential role for NFI-C/CTF transcription-replication factor in tooth root development. Molec. Cell. Biol. 23: 1075-1084, 2003.