Anti-NFIC/CTF Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Nuclear factor 1 C-type is a protein that in humans is encoded by the NFIC gene. It is mapped to 19p13.3. The protein encoded by this gene belongs to the CTF/NF-I family. These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for adenovirus DNA replication. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Synonyms
Nuclear factor 1 C-type; NF1-C; Nuclear factor 1/C; CCAAT-box-binding transcription factor; CTF; Nuclear factor I/C; NF-I/C; NFI-C; TGGCA-binding protein; NFIC; NFI
Gene Name
NFIC
Gene ID
4782
UniProt
P08651
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human NFIC/CTF recombinant protein (Position: D215-G508) .
Clonality
Polyclonal
Tissue Specificity
Mainly expressed in testis. Isoform 3 is expressed predominantly in adult testis, weakly in pancreas, embryonic testis and sperm, and at very low levels in other organs.
Applications
Flow Cytometry
Field of Research
Adapters, Cell Type Marker, Intracellular Signaling, Neuron Marker, Neuroscience, Neurotransmission, Synapse Marker
Purification
Immunogen affinity purified.
Form
Liquid
Function
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
References & Citations
1. Grunder, A., Qian, F., Ebel, T. T., Mincheva, A., Lichter, P., Kruse, U., Sippel, A. E. Genomic organization, splice products and mouse chromosomal localization of genes for transcription factor nuclear factor one. Gene 304: 171-181, 2003. 2. Qian, F., Kruse, U., Lichter, P., Sippel, A. E. Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH. Genomics 28: 66-73, 1995. 3. Steele-Perkins, G., Butz, K. G., Lyons, G. E., Zeichner-David, M., Kim, H.-J., Cho, M.-I., Gronostajski, R. M. Essential role for NFI-C/CTF transcription-replication factor in tooth root development. Molec. Cell. Biol. 23: 1075-1084, 2003.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
90314 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Nuclear factor I C
Subcellular Location
Nucleus.
Protein Name
Chromodomain-helicase-DNA-binding protein 2
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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