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Anti-LIPC Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Hepatic lipase (HL), also called hepatic triglyceride lipase (HTGL) or LIPC (for lipase, hepatic), is a form of lipase, catalyzing the hydrolysis of triacylglyceride. It is mapped to 8q24. LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake.

Synonyms

Hepatic triacylglycerol lipase; HL; Hepatic lipase; Lipase member C; Lipc

Gene Name

Lipc

Gene ID

24538

UniProt

P07867

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived rat LIPC recombinant protein (Position: E39-D494) .

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

Cell Type Marker, Cell Type Markers, Neurodegenerative Disease, Neurology Process, Neuroscience, Tags & Cell Markers

Purification

Immunogen affinity purified.

Form

Liquid

Function

Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin.

References & Citations

1. Ameis, D., Stahnke, G., Kobayashi, J., McLean, J., Lee, G., Buscher, M., Schotz, M. C., Will, H. Isolation and characterization of the human hepatic lipase gene. J. Biol. Chem. 265: 6552-6555, 1990. 2. Brown, R. J., Gauthier, A., Parks, R. J., McPherson, R., Sparks, D. L., Schultz, J. R., Yao, Z. Severe hypoalphalipoproteinemia in mice expressing human hepatic lipase deficient in binding to heparan sulfate proteoglycan. J. Biol. Chem. 279: 42403-42409, 2004. 3. Cai, S.-J., Wong, D. M., Chen, S.-H., Chan, L. Structure of the human hepatic triglyceride lipase gene. Biochemistry 28: 8966-8971, 1989.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

47579 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Lipase C, hepatic type

Subcellular Location

Secreted.

Protein Name

2',3'-cyclic-nucleotide 3'-phosphodiesterase

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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