Anti-LIPC Antibody Picoband® Fluoro550 Conjugated
Product Specifications
Background
Hepatic lipase (HL), also called hepatic triglyceride lipase (HTGL) or LIPC (for lipase, hepatic), is a form of lipase, catalyzing the hydrolysis of triacylglyceride. It is mapped to 8q24. LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake.
Synonyms
Hepatic triacylglycerol lipase; HL; Hepatic lipase; Lipase member C; Lipc
Gene Name
Lipc
Gene ID
24538
UniProt
P07867
Host
Rabbit
Reactivity
Human, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived rat LIPC recombinant protein (Position: E39-D494) .
Clonality
Polyclonal
Applications
Flow Cytometry
Field of Research
Cell Type Marker, Cell Type Markers, Neurodegenerative Disease, Neurology Process, Neuroscience, Tags & Cell Markers
Purification
Immunogen affinity purified.
Form
Liquid
Function
Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin.
References & Citations
1. Ameis, D., Stahnke, G., Kobayashi, J., McLean, J., Lee, G., Buscher, M., Schotz, M. C., Will, H. Isolation and characterization of the human hepatic lipase gene. J. Biol. Chem. 265: 6552-6555, 1990. 2. Brown, R. J., Gauthier, A., Parks, R. J., McPherson, R., Sparks, D. L., Schultz, J. R., Yao, Z. Severe hypoalphalipoproteinemia in mice expressing human hepatic lipase deficient in binding to heparan sulfate proteoglycan. J. Biol. Chem. 279: 42403-42409, 2004. 3. Cai, S.-J., Wong, D. M., Chen, S.-H., Chan, L. Structure of the human hepatic triglyceride lipase gene. Biochemistry 28: 8966-8971, 1989.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
47579 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Lipase C, hepatic type
Subcellular Location
Secreted.
Protein Name
2',3'-cyclic-nucleotide 3'-phosphodiesterase
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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