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Anti-IFT88 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Intraflagellar transport protein 88 homolog is a protein that in humans is encoded by the IFT88 gene. It is mapped to 13q12.11. This gene encodes a member of the tetratrico peptide repeat (TPR) family. The encoded protein is involved in cilium biogenesis. Mutations of a similar gene in mouse can cause polycystic kidney disease. Several transcript variants encoding distinct isoforms have been identified for this gene.

Synonyms

Intraflagellar transport protein 88 homolog; Recessive polycystic kidney disease protein Tg737 homolog; Tetratricopeptide repeat protein 10; TPR repeat protein 10; IFT88; TG737; TTC10

Gene Name

IFT88

Gene ID

8100

UniProt

Q13099

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human IFT88 recombinant protein (Position: E198-K814) .

Clonality

Polyclonal

Tissue Specificity

Expressed in the heart, brain, liver, lung, kidney, skeletal muscle and pancreas.

Applications

Flow Cytometry

Field of Research

Cell Adhesion Proteins, ECM Proteins, Neuroscience

Purification

Immunogen affinity purified.

Form

Liquid

Function

Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.

References & Citations

1. Cano, D. A., Murcia, N. S., Pazour, G. J., Hebrok, M. orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization. Development 131: 3457-3467, 2004. 2. Delaval, B., Bright, A., Lawson, N. D., Doxsey, S. The cilia protein IFT88 is required for spindle orientation in mitosis. Nature Cell Biol. 13: 461-468, 2011. 3. Huangfu, D., Liu, A., Rakeman, A. S., Murcia, N. S., Niswander, L., Anderson, K. V. Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature 426: 83-87, 2003.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

104553 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Intraflagellar transport 88

Subcellular Location

Centriole. Cilium basal body. Centrosome. Cilium. Cytoplasm. Flagellum.

Protein Name

AP-2 complex subunit beta

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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