Anti-FGF10 Antibody Picoband® Fluoro647 Conjugated

Fibroblast growth factor 10 is a protein that in humans is encoded by the FGF10 gene. It is mapped to 5p12. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing.

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.

1. Bagai, S., Rubio, E., Cheng, J.-F., Sweet, R., Thomas, R., Fuchs, E., Grady, R., Mitchell, M., Bassuk, J. A. Fibroblast growth factor-10 is a mitogen for urothelial cells. J. Biol. Chem. 277: 23828-23837, 2002. 2. Dong, P. D. S., Munson, C. A., Norton, W., Crosnier, C., Pan, X., Gong, Z., Neumann, C. J., Stainier, D. Y. R. Fgf10 regulates hepatopancreatic ductal system patterning and differentiation. Nature Genet. 39: 397-402, 2007. 3. Emoto, H., Tagashira, S., Mattei, M.-G., Yamasaki, M., Hashimoto, G., Katsumata, T., Negoro, T., Nakatsuka, M., Birnbaum, D., Coulier, F., Itoh, N. Structure and expression of human fibroblast growth factor-10. J. Biol. Chem. 272: 23191-23194, 1997.