Anti-EAPP Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
E2F-associated phosphoprotein is a protein that in humans is encoded by the EAPP gene. It is mapped to 14q13.1. This gene encodes a phosphoprotein that interacts with several members of the E2F family of proteins. The protein localizes to the nucleus, and is present throughout the cell cycle except during mitosis. It functions to modulate E2F-regulated transcription and stimulate proliferation. Alternative splicing results in multiple transcript variants.
Synonyms
E2F-associated phosphoprotein; EAPP; C14orf11; BM-036
Gene Name
EAPP
Gene ID
55837
UniProt
Q56P03
Host
Rabbit
Reactivity
Human, Mouse
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human EAPP recombinant protein (Position: M1-S285) .
Clonality
Polyclonal
Tissue Specificity
Ubiquitously expressed. Highest levels in heart, placenta, skeletal muscle and pancreas. Lower levels in brain, lung and kidney. In the brain, expressed in all regions with high levels in the cerebellum and cerebral cortex. Expressed in COS1 and transformed skin fibroblasts.
Applications
Flow Cytometry
Field of Research
Interleukins
Purification
Immunogen affinity purified.
Form
Liquid
Function
May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14 (ARP) expression.
References & Citations
1. Kamnasaran, D., Chen, C.-P., Devriendt, K., Mehta, L., Cox, D. W. Defining a holoprosencephaly locus on human chromosome 14q13 and characterization of potential candidate genes. Genomics 85: 608-621, 2005. 2. Novy, M., Pohn, R., Andorfer, P., Novy-Weiland, T., Galos, B., Schwarzmayr, L., Rotheneder, H. EAPP, a novel E2F binding protein that modulates E2F-dependent transcription. Molec. Biol. Cell 16: 2181-2190, 2005.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
67166 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
E2F associated phosphoprotein
Subcellular Location
Nucleus. Cytoplasm.
Protein Name
Suppressor of tumorigenicity 7 protein
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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