Anti-CDR2 Antibody Picoband® Fluoro647 Conjugated

Cerebellar degeneration-related protein 2 is a protein that in humans is encoded by the CDR2 gene. By a combination of study of rodent/human somatic cell hybrids and in situ hybridization, this gene is assigned to 16p13.1-p12. The onconeuronal cerebellar degeneration-related antigen Cdr2 is associated with paraneoplastic syndromes. Neoplastic expression of Cdr2 in ovary and breast tumors triggers an autoimmune response that suppresses tumor growth by developing tumor immunity, but culminates in cerebellar degeneration when Cdr2-specific immune cells recognize neuronal Cdr2.

Expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain.

Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1 (By similarity) . .

1. Fletcher, C. F., Okano, H. J., Gilbert, D. J., Yang, Y., Yang, C., Copeland, N. G., Jenkins, N. A., Darnell, R. B. Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens. Genomics 45: 313-319, 1997. 2. Furneaux, H. M., Rosenblum, M. K., Dalmau, J., Wong, E., Woodruff, P., Graus, F., Posner, J. B. Selective expression of Purkinje-cell antigens in tumor tissue from patients with paraneoplastic cerebellar degeneration. New Eng. J. Med. 322: 1844-1851, 1990. 3. Gress, T., Baldini, A., Rocchi, M., Furneaux, H., Posner, J. B., Siniscalco, M. In situ mapping of the gene coding for a leucine zipper DNA binding protein (CDR 2) to the region between two rare fragile sites of autosome 16 (16p12-p13.1) . (Abstract) Cytogenet. Cell Genet. 58: 1999-2000, 1991.