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Anti-Cyclin B1/CCNB1 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

G2/mitotic-specific cyclin-B1 is a protein that in humans is encoded by the CCNB1 gene. It is mapped to 5q13.2. The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34 (cdc2) to form the maturation-promoting factor (MPF) . The encoded protein is necessary for proper control of the G2/M transition phase of the cell cycle.

Synonyms

G2/mitotic-specific cyclin-B1; CCNB1; CCNB

Gene Name

CCNB1

Gene ID

891

UniProt

P14635

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Cyclin B1/CCNB1 recombinant protein (Position: M1-L383) .

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

Cancer, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Essential for the control of the cell cycle at the G2/M (mitosis) transition.

References & Citations

1. Matsuo, T., Yamaguchi, S., Mitsui, S., Emi, A., Shimoda, F., Okamura, H. Control mechanism of the circadian clock for timing of cell division in vivo. Science 302: 255-259, 2003. 2. Milatovich, A., Francke, U. Human cyclin B1 gene (CCNB1) assigned to chromosome 5 (q13-qter) . Somat. Cell Molec. Genet. 18: 303-307, 1992. 3. Moore, J. D., Kirk, J. A., Hunt, T. Unmasking the S-phase-promoting potential of cyclin B1. Science 300: 987-990, 2003.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

51658 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Cyclin B1

Subcellular Location

Centrosome. Nucleus. Cytoplasm.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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