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Anti-ALKBH5 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

RNA demethylase ALKBH5 is an enzyme that in humans is encoded by the ALKBH5 gene. It is mapped to 17p11.2. N (6) -methyladenosine (m (6) A) is the most prevalent modification of mRNA. ALKBH5 functions as a demethylase that removes m (6) A from mRNAs.

Synonyms

RNA demethylase ALKBH5; Alkylated DNA repair protein alkB homolog 5; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5; ALKBH5; ABH5; OFOXD1

Gene Name

ALKBH5

Gene ID

54890

UniProt

Q6P6C2

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human ALKBH5 recombinant protein (Position: E81-R180) .

Clonality

Polyclonal

Tissue Specificity

Widely expressed, with highest expression in lung, followed by testis, pancreas, spleen and ovary.

Applications

Flow Cytometry

Field of Research

Adaptive Immunity, Immunology, Lipid Signaling, Signal Transduction, Signaling Pathway, T Cells

Purification

Immunogen affinity purified.

Form

Liquid

Function

Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N6-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Can also demethylate N6-methyladenosine in single-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export. Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells.

References & Citations

1. Hartz, P. A. Personal Communication. Baltimore, Md. 3/12/2010. 2. Tsujikawa, K., Koike, K., Kitae, K., Shinkawa, A., Arima, H., Suzuki, T., Tsuchiya, M., Makino, Y., Furukawa, T., Konishi, N., Yamamoto, H. Expression and sub-cellular localization of human ABH family molecules. J. Cell. Molec. Med. 11: 1105-1116, 2007. 3. Zheng, G., Dahl, J. A., Niu, Y., Fedorcsak, P., Huang, C.-M., Li, C. J., Vagbo, C. B., Shi, Y., Wang, W.-L., Song, S.-H., Lu, Z., Bosmans, R. P. G., and 16 others. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Molec. Cell 49: 18-29, 2013.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

AlkB homolog 5, RNA demethylase

Subcellular Location

Nucleus speckle.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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