What sizes are available for Anti-Synaptophysin/SYP Picoband® Antibody Fluoro647 Conjugated?

Anti-Synaptophysin/SYP Picoband® Antibody Fluoro647 Conjugated is available in the following size(s): 100 µg/Vial.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.

Do you offer bulk or custom quantities of this product?

Yes. Ordering two or more units, or combining this with other products, usually qualifies for a discount depending on quantity. Contact our sales team with your required volume for a custom quote.

Anti-Synaptophysin/SYP Picoband® Antibody Fluoro647 Conjugated

Q: What is the catalog number for Anti-Synaptophysin/SYP Picoband® Antibody Fluoro647 Conjugated?

The catalog number for Anti-Synaptophysin/SYP Picoband® Antibody Fluoro647 Conjugated is A05049-Fluoro647.

Selected Variant

A05049-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

Synaptophysin, also known as the major synaptic vesicle protein p38, is a protein that in humans is encoded by the SYP gene. It is mapped to Xp11.23. This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with an X-linked form of cognitive disability.

Synonyms

Synaptophysin; Major synaptic vesicle protein p38; SYP

Gene Name

SYP

Gene ID

6855

UniProt

P08247

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human Synaptophysin/SYP, which shares 91.3% amino acid (aa) sequence identity with both mouse and rat Synaptophysin/SYP.

Clonality

Polyclonal

Tissue Specificity

Ubiquitous in adult tissues. Detected in osteoblasts of the perichondrium in the developing limb of 12-week old embryos. Isoform 1 is detected in fetal brain, lung, kidney and testis. Isoform 2 is detected in fetal testis, and at much lower levels in fetal brain, lung and kidney.

Applications

Flow Cytometry

Field of Research

Angiogenesis, Cardiovascular, Cytokines, Immunology, Innate Immunity

Purification

Immunogen affinity purified.

Form

Liquid

Function

Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity.

References & Citations

1. Cremin, S. M., Greer, W. L., Bodok-Nutzati, R., Schwartz, M., Peacocke, M., Siminovitch, K. A. Linkage of Wiskott-Aldrich syndrome with three marker loci, DXS426, SYP and TFE3, which map to the Xp11.3-p11.22 region. Hum. Genet. 92: 250-253, 1993. 2. Janz, R., Sudhof, T. C., Hammer, R. E., Unni, V., Siegelbaum, S. A., Bolshakov, V. Y. Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I. Neuron 24: 687-700, 1999. 3. Kwon, S. E., Chapman, E. R. Synaptophysin regulates the kinetics of synaptic vesicle endocytosis in central neurons. Neuron 70: 847-854, 2011.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

25847 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

Synaptophysin

Subcellular Location

Synaptic vesicle membrane. Multi-pass membrane protein. Synaptosome.

Protein Name

Uncharacterized protein

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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