Anti-Synaptophysin/SYP Picoband® Antibody Fluoro647 Conjugated
Product Specifications
Background
Synaptophysin, also known as the major synaptic vesicle protein p38, is a protein that in humans is encoded by the SYP gene. It is mapped to Xp11.23. This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with an X-linked form of cognitive disability.
Synonyms
Synaptophysin; Major synaptic vesicle protein p38; SYP
Gene Name
SYP
Gene ID
6855
UniProt
P08247
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human Synaptophysin/SYP, which shares 91.3% amino acid (aa) sequence identity with both mouse and rat Synaptophysin/SYP.
Clonality
Polyclonal
Tissue Specificity
Ubiquitous in adult tissues. Detected in osteoblasts of the perichondrium in the developing limb of 12-week old embryos. Isoform 1 is detected in fetal brain, lung, kidney and testis. Isoform 2 is detected in fetal testis, and at much lower levels in fetal brain, lung and kidney.
Applications
Flow Cytometry
Field of Research
Angiogenesis, Cardiovascular, Cytokines, Immunology, Innate Immunity
Purification
Immunogen affinity purified.
Form
Liquid
Function
Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity.
References & Citations
1. Cremin, S. M., Greer, W. L., Bodok-Nutzati, R., Schwartz, M., Peacocke, M., Siminovitch, K. A. Linkage of Wiskott-Aldrich syndrome with three marker loci, DXS426, SYP and TFE3, which map to the Xp11.3-p11.22 region. Hum. Genet. 92: 250-253, 1993. 2. Janz, R., Sudhof, T. C., Hammer, R. E., Unni, V., Siegelbaum, S. A., Bolshakov, V. Y. Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I. Neuron 24: 687-700, 1999. 3. Kwon, S. E., Chapman, E. R. Synaptophysin regulates the kinetics of synaptic vesicle endocytosis in central neurons. Neuron 70: 847-854, 2011.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
25847 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Synaptophysin
Subcellular Location
Synaptic vesicle membrane. Multi-pass membrane protein. Synaptosome.
Protein Name
Uncharacterized protein
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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