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Anti-SORBS1 Picoband® Antibody Fluoro647 Conjugated

Product Specifications

Background

CAP/Ponsinprotein, also known as Sorbin and SH3 domain-containing protein 1 is a protein that in humans is encoded by the SORBS1 gene. It is mapped to 10q24.1. This gene encodes a CBL-associated protein which functions in the signaling and stimulation of insulin. Mutations in this gene may be associated with human disorders of insulin resistance. Alternative splicing results in multiple transcript variants.

Synonyms

Sorbin and SH3 domain-containing protein 1; Ponsin; SH3 domain protein 5; SH3P12; c-Cbl-associated protein; CAP; SORBS1; KIAA0894; KIAA1296; SH3D5

Gene Name

SORBS1

Gene ID

10580

UniProt

Q9BX66

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human SORBS1 recombinant protein (Position: Q23-R323) .

Clonality

Polyclonal

Tissue Specificity

Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.

Applications

Flow Cytometry

Field of Research

Cancer, Cardiovascular, Cell Type Markers, Cytokines, Growth Factors, Growth Factors/Hormones, Immunology, Innate Immunity, Signal Transduction, Tags & Cell Markers, TNF Superfamily, Vasculature

Purification

Immunogen affinity purified.

Form

Liquid

Function

Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions.

References & Citations

1. Lin, W.-H., Chiu, K. C., Chang, H.-M., Lee, K.-C., Tai, T.-Y., Chuang, L.-M. Molecular scanning of the human sorbin and SH3-domain-containing-1 (SORBS1) gene: positive association of the T228A polymorphism with obesity and type 2 diabetes. Hum. Molec. Genet. 10: 1753-1760, 2001. 2. Mastick, C. C., Brady, M. J., Saltiel, A. R. Insulin stimulates the tyrosine phosphorylation of caveolin. J. Cell Biol. 129: 1523-1531, 1995. 3. Ribon, V., Printen, J. A., Hoffman, N. G., Kay, B. K., Saltiel, A. R. A novel, multifunctional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes. Molec. Cell. Biol. 18: 872-879, 1998.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

143 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Sorbin and SH3 domain containing 1

Subcellular Location

Cell membrane. Nucleus. Nucleus matrix. Cytoskeleton. Adherens junction. Focal adhesion.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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