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Anti-Polymeric immunoglobulin receptor/PIGR Picoband® Antibody Fluoro550 Conjugated

Product Specifications

Background

Polymeric immunoglobulin receptor (pIgR) is a transmembrane protein that in humans is encoded by the PIGR gene. It is mapped to 1 E4; 1 56.89 cM. This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.

Synonyms

Polymeric immunoglobulin receptor; PIgR; Poly-Ig receptor; Secretory component; Pigr

Gene Name

Pigr

Gene ID

18703

UniProt

O70570

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived mouse Polymeric immunoglobulin receptor/PIGR recombinant protein (Position: D34-A771) .

Clonality

Polyclonal

Tissue Specificity

Expressed in all tissues examined.

Applications

Flow Cytometry

Field of Research

Chromatin Modifying Enzymes, DNA/Nucleotides, DNA/RNA, Epigenetics and Nuclear Signaling

Purification

Immunogen affinity purified.

Form

Liquid

Function

This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.

References & Citations

1. Davidson, M. K., Le Beau, M. M., Eddy, R. L., Shows, T. B., DiPietro, L. A., Kingzette, M., Hanly, W. C. Genetic mapping of the human polymeric immunoglobulin receptor gene to chromosome region 1q31-q41. Cytogenet. Cell Genet. 48: 107-111, 1988. 2. Hood, L., Kronenberg, M., Hunkapiller, T. T cell antigen receptors and the immunoglobulin supergene family. Cell 40: 225-229, 1985. 3. Krajci, P., Gedde-Dahl, T., Jr., Hoyheim, B., Rogde, S., Olaisen, B., Brandtzaeg, P. The gene encoding human transmembrane secretory component (locus PIGR) is linked to D1S58 on chromosome 1. Hum. Genet. 90: 215-219, 1992.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Polymeric immunoglobulin receptor

Subcellular Location

Cell membrane. Single-pass type I membrane protein. Secreted.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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