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Anti-Pannexin 2/PANX2 Picoband® Antibody Fluoro488 Conjugated

Product Specifications

Background

Pannexin 2 is a protein that in humans is encoded by the PANX2 gene. It is mapped to 22q13.33. The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms

Pannexin-2; PANX2

Gene Name

PANX2

Gene ID

56666

UniProt

Q96RD6

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Pannexin 2/PANX2 recombinant protein (Position: E19-F677) .

Clonality

Polyclonal

Tissue Specificity

Expressed in fetal and adult brain. Also detected in fetal liver and skeletal muscle, but not in their adult counterparts.

Applications

Flow Cytometry

Field of Research

Organelles, Subcellular Markers, Tags & Cell Markers

Purification

Immunogen affinity purified.

Form

Liquid

Function

Structural component of the gap junctions and the hemichannels.

References & Citations

1. Bruzzone, R., Hormuzdi, S. G., Barbe, M. T., Herb, A., Monyer, H. Pannexins, a family of gap junction proteins expressed in brain. Proc. Nat. Acad. Sci. 100: 13644-13649, 2003. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 1/23/2004.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Pannexin 2

Subcellular Location

Cell membrane. Multi-pass membrane protein. Gap junction.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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