Anti-Menin/MEN1 Picoband® Antibody Fluoro488 Conjugated

Menin is a protein that in humans is encoded by the MEN1 gene. It is mapped to 11q13.1. This gene encodes menin, a tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. Menin is a scaffold protein that functions in histone modification and epigenetic gene regulation. It is thought to regulate several pathways and processes by altering chromatin structure through the modification of histones.

Apoptosis, Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Intracellular, Kinases, Nuclear Signaling Pathways, Oncoproteins, Oncoproteins/Suppressors, Protein Phosphorylation, Signal Transduction, Tyrosine Kinases

Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4) . Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity) . May be involved in DNA repair.

1. Agarwal, S. K., Kester, M. B., Debelenko, L. V., Heppner, C., Emmert-Buck, M. R., Skarulis, M. C., Doppman, J. L., Kim, Y. S., Lubensky, I. A., Zhuang, Z., Green, J. S., Guru, S. C., Manickam, P., Olufemi, S.-E., Liotta, L. A., Chandrasekharappa, S. C., Collins, F. S., Spiegel, A. M., Burns, A. L., Marx, S. J. Germline mutations of the MEN1 gene in familial multiple endocrine neoplasia type 1 and related states. Hum. Molec. Genet. 6: 1169-1175, 1997. 2. Balogh, K., Patocs, A., Majnik, J., Varga, F., Illyes, G., Hunyady, L., Racz, K. Unusual presentation of multiple endocrine neoplasia type 1 in a young woman with a novel mutation of the MEN1 gene. J. Hum. Genet. 49: 380-386, 2004. 3. Boni, R., Vortmeyer, A. O., Pack, S., Park, W.-S., Burg, G., Hofbauer, G., Darling, T., Liotta, L., Zhuang, Z. Somatic mutations of the MEN1 tumor suppressor gene detected in sporadic angiofibromas. (Letter) J. Invest. Derm. 111: 539-540, 1998.