Anti-MAFA Picoband® Antibody Fluoro647 Conjugated
Product Specifications
Background
MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene. It is mapped to 8q24.3.
Synonyms
Transcription factor MafA; Pancreatic beta-cell-specific transcriptional activator; RIPE3b1 factor; V-maf musculoaponeurotic fibrosarcoma oncogene homolog A; MAFA
Gene Name
MAFA
Gene ID
389692
UniProt
Q8NHW3
Host
Rabbit
Reactivity
Human, Mouse
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human MAFA recombinant protein (Position: A9-D308) .
Clonality
Polyclonal
Tissue Specificity
Preferentially expressed in regulatory T-cells (Tregs) .
Applications
Flow Cytometry
Field of Research
Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Transcription factor that activates insulin gene expression. Acts synergistically with NEUROD1/BETA2 and PDX1. Binds the insulin enhancer C1/RIPE3b element. Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence.
References & Citations
1. Iacovazzo, D., Flanagan, S. E., Walker, E., Quezado, R., de Sousa Barros, F. A., Caswell, R., Johnson, M. B., Wakeling, M., Brandle, M., Guo, M., Dang, M. N., Gabrovska, P., and 14 others. MAFA missense mutation causes familial insulinomatosis and diabetes mellitus. Proc. Nat. Acad. Sci. 115: 1027-1032, 2018. 2. Olbrot, M., Rud, J., Moss, L. G., Sharma, A. Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA. Proc. Nat. Acad. Sci. 99: 6737-6742, 2002. 3. Tragl, K.-H., Mayr, W. R. Familial islet-cell adenomatosis. Lancet 318: 426-428, 1977. Note: Originally Volume II.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
39411 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
MAF bZIP transcription factor A
Subcellular Location
Nucleus.
Protein Name
Zinc finger protein Helios
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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