Anti-LRRC32 Picoband® Antibody

Leucine-rich repeat protein 32 (LRRC32), also known as GARP (glycoprotein A repetitions predominant), is an 80 kDa type I transmembrane glycoprotein. It is mapped to 11q13.5. This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies.

Transforming growth factor beta activator LRRC32; Garpin; Glycoprotein A repetitions predominant; GARP; Leucine-rich repeat-containing protein 32; LRRC32; D11S833E

Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta. Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs) . Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (By similarity) .

1. Lienart, S., Merceron, R., Vanderaa, C., Lambert, F., Colau, D., Stockis, J., van der Woning, B., De Haard, H., Saunders, M., Coulie, P. G., Savvides, S. N., Lucas, S. Structural basis of latent TGF-beta-1 presentation and activation by GARP on human regulatory T cells. Science 362: 952-956, 2018. 2. Ollendorff, V., Noguchi, T., deLapeyriere, O., Birnbaum, D. The GARP gene encodes a new member of the family of leucine-rich repeat-containing proteins. Cell Growth Diff. 5: 213-219, 1994. 3. Ollendorff, V., Szepetowski, P., Mattei, M.-G., Gaudray, P., Birnbaum, D. New gene in the homologous human 11q13-q14 and mouse 7F chromosomal regions. Mammalian Genome 2: 195-200, 1992.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.