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Anti-GPNMB/Gpnmb Picoband® Antibody Fluoro647 Conjugated

Product Specifications

Background

Transmembrane glycoprotein NMB is a protein that in humans is encoded by the GPNMB gene. It is mapped to 6 B2.3; 6 23.82 cM. The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.

Synonyms

Transmembrane glycoprotein NMB; DC-HIL; Dendritic cell-associated transmembrane protein; Osteoactivin; Gpnmb; Dchil; Hgfin; ; Nmb

Gene Name

Gpnmb

Gene ID

93695

UniProt

Q99P91

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived mouse GPNMB/Gpnmb recombinant protein (Position: R164-D564) .

Clonality

Polyclonal

Tissue Specificity

Monocyte/macrophage specific.

Applications

Flow Cytometry

Field of Research

Immunoglobulins, Immunology, Innate Immunity

Purification

Immunogen affinity purified.

Form

Liquid

Function

Could be a melanogenic enzyme.

References & Citations

1. Lu, H., Wang, X., Pullen, M., Guan, H., Chen, H., Sahu, S., Zhang, B., Chen, H., Williams, R. W., Geisert, E. E., Lu, L., Jablonski, M. M. Genetic dissection of the Gpnmb network in the eye. Invest. Ophthal. Vis. Sci. 52: 4132-4142, 2011. 2. Weterman, M. A. J., Ajubi, N., van Dinter, I. M. R., Degen, W. G. J., van Muijen, G. N. P., Ruiter, D. J., Bloemers, H. P. J. Nmb, a novel gene, is expressed in low-metastatic human melanoma cell lines and xenografts. Int. J. Cancer 60: 73-81, 1995. 3. Yang, C.-F., Lin, S.-P., Chiang, C.-P., Wu, Y.-H., H'ng, W. S., Chang, C.-P., Chen, Y.-T., Wu, J.-Y. Loss of GPNMB causes autosomal-recessive amyloidosis cutis dyschromica in humans. Am. J. Hum. Genet. 102: 219-232, 2018.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

38779 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Glycoprotein (transmembrane) nmb

Subcellular Location

Cell membrane. Single-pass type I membrane protein.

Protein Name

BAG family molecular chaperone regulator 1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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